OSPA Glycol Ethers EGBE classification
Following the 33rd CARACAL (Jan 2020) meeting, with respect to the future classification of EGBE, the Commission asked RAC for a re-evaluation for inhalation toxicity, as a result of a new study results submitted by industry.
EGBE is known to cause severe haemolysis in some animal species especially in rats, mice and rabbits and this haemolysis is the main cause of toxic effects seen in these species. Guinea pigs and humans are resistant to the effect of haemolysis induced by EGBE exposure. For this reason it is more appropriate to use these data on guinea pigs to predict the toxicity in humans than data on rats, mice and rabbits. The new study conducted had no guinea pigs dying due the inhalation of EGBE.
However, the RAC did not deviate from its first assessment. Following the latest CARACAL (41st in October 21) and despite several inputs to the discussions at previous meetings, the Commission followed the recommendation of the RAC in the end. ATP 18 to the CLP will thus list additionally Acute Tox 3 Inhalation for EGBE. As the EBGE manufacturers still believe that the evidence available should lead to a different listing, they will publish the study results and will contribute to the organisation of a workshop on inhalation toxicity.
ATP 18 to the CLP will thus list for EGBE additionally Acute Tox 3 Inhalation.
EBGE manufacturers still believe that this is against the evidence available.
We will publish the study results and also contribute to the organisation of a workshop on inhalation toxicity.